The changes of plasma angiotensin Ⅱ and cathecholaminesin canine endotoxic shock / 中国病理生理杂志

After injection of endotoxin, the hemodynamic changes, plasma angiotensin (Ag) Ⅱ and cathecholamines (CAs) in dogs were studied. It indicated that the changes of plasma AgⅡ and CAs were most probably compensatory in nature and secondary to the low cardiac output and low peripheral resistance caused by other factors. During the compensatory period, both plasma AgⅡ and CAs were closed to the pre-injection levels. The first peak of plasma CAs was around five minutes, while that of AgⅡ around thirty minutes after injection of endotoxin, it indicated that the changes of plasma AgⅡ was probably secondary to the adrenergic activation.